Stem cells: a promising source for vascular regenerative medicine

Abstract.

The rising and diversity of many human vascular diseases pose urgent needs for the development of novel therapeutics. Stem cell therapy represents a challenge in the medicine of the twenty-first century, an area where tissue engineering and regenerative medicine gather to provide promising treatments for a wide variety of diseases. Indeed, with their extensive regeneration potential and functional multilineage differentiation capacity, stem cells are now highlighted as promising cell sources for regenerative medicine. Their multilineage differentiation involves environmental factors such as biochemical, extracellular matrix coating, oxygen tension, and mechanical forces. In this review, we will focus on human stem cell sources and their applications in vascular regeneration. We will also discuss the different strategies used for their differentiation into both mature and functional smooth muscle and endothelial cells.

PMID: 25167472 DOI:10.1089/scd.2014.0132
PHassan Rammal 1, Chaza Harmouch, Jean-Jacques Lataillade, Dominique Laurent-Maquin, Pierre Labrude, Patrick Menu, Halima Kerdjoudj

Online Ahead of Print:September 26, 2014
Online Ahead of Editing: August 28, 2014
Published in Volume: 23 Issue 24: August 28, 2014