Transplanting Mesenchymal Stem Cells for Treatment of Ischemic Stroke

Abstract.

Stroke is a major disease that leads to high mortality and morbidity. Given the ageing population and the potential risk factors, the prevalence of stroke and socioeconomic burden associated with stroke are expected to increase. During the past decade, both prophylactic and therapeutic strategies for stroke have made significant progress. However, current therapies still cannot adequately improve the outcomes of stroke and may not apply to all patients. One of the significant advances in modern medicine is cell-derived neurovascular regeneration and neuronal repair. Progress in stem cell biology has greatly contributed to ameliorating stroke-related brain injuries in preclinical studies and demonstrated clinical potential in stroke treatment. Mesenchymal stem cells (MSCs) have the differentiating potential of chondrocytes, adipocytes, and osteoblasts, and they have the ability to transdifferentiate into endothelial cells, glial cells, and neurons. Due to their great plasticity, MSCs have drawn much attention from the scientific community. This review will focus on MSCs, stem cells widely utilized in current medical research, and evaluate their effect and potential of improving outcomes in ischemic stroke.

Keywords: Ischemic stroke; MSCs; stem cell replacement.

PMID: 30251564 DOI:10.1177/0963689718795424
Fan Wang, Hailiang Tang, Jianhong Zhu, John H. Zhang

First Published September 25, 2018 Research Article Find in PubMed
Article first published online: September 25, 2018; Issue published: December 1, 2018